The title is a play on the phrase "nay sayers"...
...which denotes someone who complains, criticizes, or objects to something!
Kookie is an aspiring young actress look for her big break.
Her friend, Jose O'Hara, is an aspiring playwright looking for his big break.
In this never-reprinted tale from Dell's Kookie! #1 (1962), scripted by John Stanley and illustrated by Bill Williams, the two encourage each other's "creativity" with almost insane optimism, trying to turn each setback into an advantage!
