An astronaut returns from space and doesn't act like himself...
...yeah, it's a bit of a cliche, but this tale from Key's Weird Mysteries #1 (1952), has a surprise gimmick to defeat the baddies!
by Walter Palais (brother of better-known Golden Age artist Rudy
Palais) and Mike Esposito, this "possession by aliens" tale manages to
present a variation of the old story with the fact that literally ANY
pain causes the parasite to flee.